Dr. Wenxia Huang working in her office at Shanghai Cancer Hospital, a subsidy of Fudan University

Dr. Wenxia Huang receiving patient at Shanghai Cancer Hospital, Subsidy of Fudan University, Shanghai

Cancer patients in the waiting room of Shanghai Cancer Hospital, Subsidy of Fudan University, Shanghai
Clinical Treatment of Carcinoma of The Elderly According to the
Theory of Traditional Chinese Medicine
By Prof Wenxia Huang, Tumor Hospital, Subsidy of Fudan University, Shanghai
Presented at the 31st Cancer Control Conference Doctors' Workshop, Los Angeles, 2003
Translated by Yehua Shen, a graduate student of Dr. Huang
Traditional Chinese Medicine (TCM) is an indispensable part of the Chinese culture and needs to be
further explored to benefit people all over the world.
Longevity for the aged is an issue drawing more and more attention. One-hundred-year life, a symbol
of health and longevity and enjoyed by a few old people, is the result of synthetic action of various
factors. In China, many old people cultivate their health and prevent senility by means of diet therapy
and Qigong in accordance with the theory of TCM. Some of them, by adopting the therapeutic
methods of TCM, have rehabilitated from carcinoma and regained health.
How to use the theory and therapeutic methods of TCM to treat carcinoma among the aged? We have
summarized a practical procedure in clinical practice. That is to differentiate the disease first and then
differentiate the Zheng (syndrome or pattern of a disease). In this way we have broaden our thinking
and selected effective therapeutic methods by integrating TCM with modern medicine. A clear distinction
of the pathological changes is quiet helpful for selecting therapeutic methods. For example, the symptoms
and signs of carcinous ulceration and benign ulceration of the stomach in the aged are of little difference.
But a careful study of the pathological changes may make a big difference. Take hepatitis among the aged
for another example. Due to long-term rest, the patients appear obese, transaminase tend to drop and there
is painin the liver region. These sings may suggest disorder of lipometabolism because the liver is the organ
that produces lipase. If it is proved to be fatty liver by test, the rise of transaminase cannot be effectively
stopped by Chun Pencao (Herba Sedi, stringy stonecrop herb) or Wuweizi (Fructus Schisandrae;
fruit of Chinese magnoliavine). So for the treatment of the aged, we have to explore the causes as well
as the pathological, physiological and biochemical changes. Besides, we must pay much attention to the
changes of diseases in their process of progress. Take hepatocarcinoma and ascites due to cirrhosis for
example. According to modern medicine, the ascites due to cirrhosis indicates, 1. decrease of plasma
albumin due to reduction of functional hepatocytes, increase of denatured hepatocytes and hypotrophy
of the hepatocytes; 2. portal hypertension due to change of osmotic pressure and ascites caused by
intrahepatic hyperplasia, hepatojugular reflux disturbance and oozing of lumph containing high protein
from the surface of the liver; 3. the kidney and the endocrine factors because the reduction of the blood
volume in the kidney leads to reduced glomercular filtration rate, re-distribution of the blood in the kidney,
secondary increase of aldosterone, and reduced inactivation of the liver which results in the increase of
aldosterone, antidiuretic harmone and retention of urine. The advantage of the modern medicine in treating
ascites due to cirrhosis lies in the third aspect mentioned above. A part from limiting the absorption of
sodium, modern medicine makes use of other diuretics at different stages to increase glomerular filtration
rate, decrease re-absorption of the renal tubules or resist aldosterone.
According to the theory of TCM, hepatocarcinoma and ascites due to cirrhosis in the aged pertain to the
Zhenghou (Syndrome or Pattern) of Qi Stagnation and Blood Stasis. To treat such a problem, the
therapy for soothing the liver and regulating Qi alone does not work well. Since stasis and obstruction
also can lead to stagnation of Qi, stasis is the major problem. Cirrhosis tends to occur after hepatitis.
That is why there are the symptoms of retention of Damp-Heat and Consumption of Yin at the advanced
stage. The major problem at the advanced stage is Heat. According to the theory of TCM, ascites and
dropsy of the lower limbs are usually caused by failure of the spleen to transform water. According to the
literature concerning the relationship between the biopsy of the liver and the clinical symptoms, pathologically
there often find the formation of pseudolobuli, hyperplasia of fibrotissues and changes of bile thrombus.
Clinically hepatosplenomeagly, varix of esophagus, jaundice and increased globulin are frequently found
among the aged patients. These problems are similar to Stasis in TCM. Pathologically, the patients with
denatured hepatocytes often show such symptoms like digestive tract disorder, reduction of albumin and
profuse ascites which are similar to Pixu (Spleen-Deficiency or Spleen-Asthenia). The patients with
swollen and distending hepatocytes, focal necrosis, inflammatory infiltration and Kupffer's cells show the
symptoms of fever, pain in the liver region, cephalin-cholesterol flocculation reaction and increase of
thymol turbidity which are similar to Heat in TCM. Such an analysis makes it clear that we can find
common ground between TCM and modern medicine. The advantages of TCM in treating the problems
lie in the first and the second factors mentioned above. The first factor is due to consumption of Yin
by Heat that damages the hepatocytes. The herbs for clearing away Heat and removing Toxin can enable
the hepatocytes to restore its function to produce albumin, such as Huangliang (Rhizoma Coptidis;
rhizome of Chinese goldthread), Huangqin (Radix Astragali; root of membranous milkvetch),
Zhanzhi (Fructus Gardeniae; fruit of cape jasmine), Longdancao (Radix Gentianae), Tianjihuang
(Herba Hyperici Japonici; Japanese St. John's wort herb), Pugongying
(Herba Taraxaci; Monolian dandelion herb) and Xiakucao (Spica Prunellae; common
selfheal spike) etc. If Heat is not cleared away, the use of albumin, adenosine triphosphale and coenzyme A
alone doe not work well. If there are no symptoms of Damp-Heat, Deficiency-Heat and Excess-Heat, the
herbs for strengthening the spleen and regulating Qi can increase albumin by improving the functions of the
hepatocytes, such as Huangqin (Radix Astragali; root of membranous milkvetch), Dangshen (Radix Codonopsis; tangshen root) and Taizishen (Ì«×Ó²ÎRadix Pseudostellariae; root of heterophylla
falsestarwort), etc. The second factor is due to the hyperplasia of fibrous tissues, formation of hepatic
pseudolobuli and unsmooth flow of blood in the liver. The herbs for activating blood and removing
stasis can soften hyperplasia diseases and promoting blood flow, therefore reducing portal hypertension.
For mild cases, Danshen (Radix Salviae Miltiorrhizae; root of red-rooted salvia), Danggui (µ±¹éRadix
Angelicae Sinensis; root of Chinese angelica), Paoshanjia (Squama Manitis Praeparata; prepared
pangolin scale) can be used. For severe cases, Xuefu Zhuyu Tang can be used with the
addition of some herbs for regulating Qi for promoting blood flow, such as Yujin (Óô½ðRadix Curcumae;
common turmeric root), Xiangfu (Rhizoma Cyperi; rhizome of nutgrass galingale) and Zhike
(Fructus Aurantii; bitter orange). The curative effect of the herbs mentioned above is proved by the research
done in the light of integrated traditional Chinese and modern medicine and clinical observation. The
pharmacological mechanism of some herbs is still unclear now and their compatibility still needs
further research. Based on the pathology and physiology as well as the differentiation of diseases
and the differentiation of Zheng (Syndrome or Pattern), a new diagnostic and therapeutic system is
developed. It is quiet effective for eliminating and preventing ascites.
In clinical practice, the disease and Zheng (Syndrome or Pattern) of many aged patients suffering
from carcinoma appear contradictory. In fact, there is some difference between clinical manifestations
and the nature of diseases. For example, hemorrhage of upper digestive tract (hepatocarcinoma or
gastrocarcinoma) is a commonly encountered emergent disease in internal medicine. To treat such a
disease, modern medicine usually use hemostatics and has no definite rules. Hemorrhage of upper
digestive tract is marked by light retention of nitrogenous substance due to long time to stop occult
hematochezia caused by retention of old hemorrhage. But modern medicine does not use purgatives
to eliminate old blood lest that rehemorrhage be caused by gastric ulcer due to increased gastrointestinal
peristalsis. According to Bianzheng (differentiation of Syndromes) in TCM, hematemesis is caused
by hyperactivity of Stomach-Fire and melena is caused by retention of stagnant blood inside the body.
If stagnant blood cannot be removed from the body, Heat in the stomach may rise again. For this reason,
Sanhuang Xiexin Tang is used. Crude Dahuang (Radix et Rhizoma Rhei; root and
rhizome of medicinal rhubarb) in this formula is effective in stopping bleeding and preventing stasis.
The combined use of Crude Dahuang (Radix et Rhizoma Rhei; root and rhizome of medicinal
rhubarb) and Baiji (Rhizoma Bletillae; tuber of common bletilla) is proved effective for stopping
bleeding and eliminating stasis. There is report about a comparative study on hemorrhage of upper
digestive tract, comparing 19 cases (gastric and duodenal ulcer proved by gastrointestinal barium meal
examination) treated by hemorrhage-stopping and stasis-eliminating therapy with 16 cases treated by
modern medicine. It has proved that the hemorrhage-stopping and stasis-eliminating therapy can
effectively and immediately stop hemorrhage, eliminate blood stasis and shorten the time for stopping
occult hematochezia, appearing helpful for deciding whether there is hemorrhage in clinical treatment.
Lung cancer and pneumonia in the aged with the symptoms of aversion to cold, fever, cough with
yellowish sputum, chest oppression and dyspnea, according to the Bianzheng (differentiation of
Syndromes) in TCM, are caused by cold in the exterior and heat in the interior or invasion of Heat into
Wefen (the defensive-phase). Though it can be treated by Yinqiao San, or Maxing Shigan
Tang, or Mahu Tang, the effect in removing Heat is slow. According to modern
medicine, they are caused by pathological changes of the lung. Aversion to cold and chills are the signs
of impending high fever. When carcinous Heat and interior inflammation are controlled, chills and fever
can be stopped immediately. It is unlike common cold. TCM believes that the disease is still superficial
at this stage and that it is necessary to bring the defensive function of the body surface into full play.
So the herbs for clearing away Heat in the lung and removing toxin can be selected to deal with fever
in lung cancer. The herbs that can be used for this purpose include Yuxingcao (Herba Houttuyniae;
heartleaf houttuynia herb), Banzhilian (Herba Portulacae Grandiflorae; largeflower purslane herb),
Yazhicao, Yeqiaomaigen and Huzhang (Polygonia Curpidati; rhizome
of Japanese fleecceflower). The herbs for relieving the superficies or dissipating Weifen (defensive
phase) should not be used.
Adoption of the advantages of both TCM and modern medicine and emphasis on the differentiation of
both diseases and Syndromes can enrich diagnostic and therapeutic methods and increase the curative
effect. Since the study on the theory of TCM is based on clinical practice, much of the clinical
experiences need to be theoretically analyzed. On the other hand, advanced scientific methods should
be used to study the essentials of TCM so as to make it more practical and scientific in guiding clinical
treatment. Such a synthetic study is also quiet beneficial to the integration of the theory of TCM and
the theory of modern medicine, paving the way for the establishment of a new system of medicine.
End of the translation
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